Dmytro Kuleba started his career in the Ministry of Foreign Affairs of Ukraine in 2003. Over the years, his portfolio included such issues as international organizations, bilateral relations with the US, promotion of Ukraine abroad and of the Foreign Ministry domestically. He left public service in 2013 to engage in the development of international cultural projects and advise politicians and businessmen on managing their reputation.

In 2014, Mr. Kuleba returned to the Foreign Ministry as Ambassador-at-Large for Strategic Communications. He introduced concepts of digital diplomacy, strategic communications, cultural diplomacy and public diplomacy into the work of the Foreign Ministry. Mr. Kuleba served as Ambassador, Permanent Representative of Ukraine to the Council of Europe. Dmytro was continuously engaged in the issues of communications, communicative wars, and foreign policy.

In 2019 he authored the book "The War for Reality. How to Prevail in the World of Fakes, Truths and Communities" (Knigolove, Ukraine).